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A flexible polyaniline-based bioelectronic patch

Abstract

Bioelectronic materials based on conjugated polymers are being developed in the hope to interface with electroresponsive tissues. We have recently demonstrated that a polyaniline chitosan patch can efficiently electro-couple with cardiac tissue modulating its electrophysiology. As a promising bioelectronic material that can be tailored to different types of devices, we investigate here the impact of varying the synthesis conditions and time of in situ polymerization of aniline on the sheet resistance of the bioelectronic patch. The sheet resistance increases significantly for samples that have either the lowest molar ratio of oxidant to monomer or the highest molar ratio of dopant to monomer, while the polymerization time does not have a significant effect on the electric properties. Conductive atomic force microscopy reveals that the patch with the lowest sheet resistance has a connected network of the conductive phase. In contrast, patches with higher sheet resistance exhibit conductive areas of lower current signal or isolated conductive islands of high current signals. Having identified the formulation that results in patches with optimal electric properties, we used it to fabricate patches that were implanted in rats for two weeks. It is shown that the patch retains an electroactive nature, and only a mild inflammation is observed with fibrous tissue encapsulating the patch.

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Publication details

The article was received on 28 Sep 2017, accepted on 08 Jan 2018 and first published on 09 Jan 2018


Article type: Paper
DOI: 10.1039/C7BM00880E
Citation: Biomater. Sci., 2018, Accepted Manuscript
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    A flexible polyaniline-based bioelectronic patch

    C. Cui, N. Faraji, A. Lauto, L. Travaglini, J. Tonkin, D. Mahns, E. Humphrey, C. Terracciano, J. J. Gooding, J. Seidel and D. Mawad, Biomater. Sci., 2018, Accepted Manuscript , DOI: 10.1039/C7BM00880E

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