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Issue 4, 2018
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Interaction of cells with patterned reactors

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Abstract

Surface coatings that allow externally controlled interaction with cells are of interested for diverse biomedical applications. We fabricated particle patterns and assessed the interaction of these substrates with endothelial cells and hepatocytes. The particles were turned into subcompartmentalized reactors by immobilizing glucose oxidase loaded liposomes sandwiched between polymer layers. The reactor activities depending on the number of liposome deposition steps were confirmed in solution and on patterned surfaces. Finally, reduced viability of hepatocytes adhering to the reactor patterned surfaces in the presence of glucose was observed due to the local production of hydrogen peroxide. This first report on patterned reactors in combination with cells opens up vast opportunities to assemble interactive nanobiointerfaces.

Graphical abstract: Interaction of cells with patterned reactors

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Publication details

The article was received on 12 Sep 2017, accepted on 09 Dec 2017 and first published on 11 Dec 2017


Article type: Paper
DOI: 10.1039/C7BM00838D
Citation: Biomater. Sci., 2018,6, 793-802
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    Interaction of cells with patterned reactors

    C. Zhu, E. M. Taipaleenmäki, Y. Zhang, X. Han and B. Städler, Biomater. Sci., 2018, 6, 793
    DOI: 10.1039/C7BM00838D

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