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SPIONs for cell labelling and tracking using MRI: magnetite or maghemite?

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Abstract

Although there is extensive literature covering the biomedical applications of superparamagnetic iron oxide nanoparticles (SPIONs), the phase of the iron oxide core used is not often taken into account when cell labelling and tracking studies for regenerative medicine are considered. Here, we use a co-precipitation reaction to synthesise particles of both magnetite- (Fe3O4) and maghemite- (γ-Fe2O3) based cores and consider whether the extra synthesis step to make maghemite based particles is advantageous for cell tracking.

Graphical abstract: SPIONs for cell labelling and tracking using MRI: magnetite or maghemite?

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Publication details

The article was received on 13 Jun 2017, accepted on 23 Nov 2017 and first published on 23 Nov 2017


Article type: Communication
DOI: 10.1039/C7BM00515F
Citation: Biomater. Sci., 2018, Advance Article
  • Open access: Creative Commons BY license
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    SPIONs for cell labelling and tracking using MRI: magnetite or maghemite?

    M. Barrow, A. Taylor, A. M. Fuentes-Caparrós, J. Sharkey, L. M. Daniels, P. Mandal, B. K. Park, P. Murray, M. J. Rosseinsky and D. J. Adams, Biomater. Sci., 2018, Advance Article , DOI: 10.1039/C7BM00515F

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