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Boron-doped diamond electrode: a modification free platform for sensitive square-wave voltammetric determination of indapamide hydrochloride

Abstract

A boron-doped diamond electrode (BDDE) was employed in the indapamide hydrochloride (IND) determination. IND presented an irreversible and diffusion-controlled oxidation peak at 0.61 V in 0.01 mol L-1 H2SO4 by cyclic voltammetry. To the development of the voltammetric method it was evaluated the effect of electrochemical pretreatment of BDDE, pH of supporting electrolyte, type of electrolyte and its concentration. Under optimized instrumental parameters of square-wave voltammetry, the IND current was linear over the range of concentration of 0.099 – 4.3 µmol L−1, with limit of detection of 56 nmol L−1. The method was successfully applied to commercial tables and the obtained results statistically similar to those obtained by a spectrophotometric method. Additionally, the determination of IND was accomplished in synthetic cerebrospinal fluid and tap water. The method proved not suffer from matrix interference with excellent recoveries.

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Publication details

The article was accepted on 11 Jun 2018 and first published on 12 Jun 2018


Article type: Paper
DOI: 10.1039/C8AY01288A
Citation: Anal. Methods, 2018, Accepted Manuscript
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    Boron-doped diamond electrode: a modification free platform for sensitive square-wave voltammetric determination of indapamide hydrochloride

    C. A. R. Salamanca-Neto, F. A. Yoshida, E. R. Sartori and J. T. Moraes, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C8AY01288A

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