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Issue 26, 2018
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Recent advances in an organ-on-a-chip: biomarker analysis and applications

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Abstract

In pharmaceutical research and development, improving the effectiveness of preclinical predictions is significant, thus in vitro and in vivo experimental models are needed to investigate human drug responses in organisms. As a microengineered model, an organ-on-a-chip (OoC) could provide reliable predictions of drug efficacy and safety by mimicking the complex biological functions of normal cellular interactions. It presents a novel platform with the advantages of high throughputs, low cost, and high efficiency for drug development. Here, we provide an outlook on the recent fundamental development of OoC studies and discuss the prospects of their applications in relation to drug discovery. In particular, we highlight a set of recently developed strategies that facilitate high-throughput analysis of biomarkers and drug metabolites on an OoC, including ELISA, PCR, LC-MS and lab-on-a-chip. A brief summary is also presented along with the prospects of this field in the future.

Graphical abstract: Recent advances in an organ-on-a-chip: biomarker analysis and applications

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Publication details

The article was received on 30 Apr 2018, accepted on 24 May 2018 and first published on 28 May 2018


Article type: Minireview
DOI: 10.1039/C8AY00970H
Citation: Anal. Methods, 2018,10, 3122-3130
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    Recent advances in an organ-on-a-chip: biomarker analysis and applications

    X. Li and T. Tian, Anal. Methods, 2018, 10, 3122
    DOI: 10.1039/C8AY00970H

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