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Split aptamer-based imaging solution for visualization of latent fingerprints

Abstract

An efficient method for detecting latent fingerprints (LFPs) is very important for personal identification in forensic science. Herein, a simple label-free strategy was designed for the visualization of LFPs by using a split aptamer-based imaging solution. The imaging solution consists of N-methyl mesoporphyrin IX (NMM) molecules and two DNA strands both embedded with split aptamers and split G-quadruplex sequences, respectively. The split aptamers were used to specifically bind with the lysozyme in the residues of LFPs, which brought the two DNA strands in proximity and resulted in the formation of G-quadruplex/NMM complex. Taking advantages of the high recognition power of aptamer and the unique fluorescence feature of G-quadruplex/NMM complex, this split aptamer-based imaging solution was successfully applied for visualization of LFPs under the irradiation of a handheld UV lamp. Furthermore, this approach was robust for visualizing LFPs on different substrates and from different volunteers. Therefore, this LFPs imaging strategy might find wide applications in forensic investigations.

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Publication details

The article was received on 13 Mar 2018, accepted on 09 Apr 2018 and first published on 16 Apr 2018


Article type: Paper
DOI: 10.1039/C8AY00538A
Citation: Anal. Methods, 2018, Accepted Manuscript
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    Split aptamer-based imaging solution for visualization of latent fingerprints

    X. Liu, X. Li, Y. Lu, J. Cao and F. Li, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C8AY00538A

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