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Ultrasensitive nanowire-based detection of HCVcoreAg in the serum using a microwave generator

Abstract

The possibility of application of a nanowire field-effect transistor biosensor, coupled with a microwave generator, for the detection of a hepatitis C protein marker – core antigen of the hepatitis C virus (HCVcoreAg) – has been studied. The surface of nanowire sensor elements was sensibilized with oligonucleotide molecular probes. This has provided biospecific capturing of HCVcoreAg target molecules onto the sensor surface. Herein, we have demonstrated that the nanowire biosensor coupled with microwave generator allows one to detect target protein molecules in buffer solution at a 10-times lower concentration, than that without the use of microwave generator. The lowest detectable HCVcoreAg concentration was determined to be ~10^(-17)М. The nanowire biosensor has also allowed us to detect HCVcoreAg in the serum both with and without the use of microwave generator.

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Publication details

The article was received on 07 Mar 2018, accepted on 03 May 2018 and first published on 03 May 2018


Article type: Paper
DOI: 10.1039/C8AY00495A
Citation: Anal. Methods, 2018, Accepted Manuscript
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    Ultrasensitive nanowire-based detection of HCVcoreAg in the serum using a microwave generator

    K. Malsagova, T. Pleshakova, R. Galiullin, A. Kaysheva, I. Shumov, M. Ilnitsky, V. Popov, A. Gluhov, A. Archakov and Y. Ivanov, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C8AY00495A

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