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A Non-enzymatic nanoceria electrode for non-invasive glucose monitoring


Nanoceria (CeO2) is a special rare earth material, which has electron transfer and catalytic ability. In this paper, an electrochemical method is used to combine CeO2 and gold nanoparticle (AuNP) on the glassy carbon electrode. It is shown that the combination can construct a catalyst-electron transfer system. The synergistic effect between CeO2 and AuNP can enable the system to mimic the enzyme-electron transfer function of glucose oxidase and increase the electron transfer rate, which can significantly increase the sensitivity and hence measure the glucose concentration through electrochemical method. The system demonstrates a high sensitivity of 1071.52 µA mM-1 cm-2, and detection limit of 2.86×10-3 mM (S/N=3) across a linear range of 0.02-0.6 mM. Moreover, with relatively low electrochemical surface area (ESA), the sensor demonstrates good stability, reproducibility, and anti-interference performance toward ascorbic acid (AA), uric acid (UA), and NaCl. The electrode therefore may be used to monitor the glucose level in human fluids, such as saliva and tears.

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Publication details

The article was received on 27 Feb 2018, accepted on 02 Apr 2018 and first published on 04 Apr 2018

Article type: Paper
DOI: 10.1039/C8AY00433A
Citation: Anal. Methods, 2018, Accepted Manuscript
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    A Non-enzymatic nanoceria electrode for non-invasive glucose monitoring

    L. Jiang, Q. Xue, C. Jiao, H. Liu, Y. Zhou, H. Ma and Q. Yang, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C8AY00433A

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