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Issue 16, 2018
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A highly selective “turn-on” fluorescent sensor for zinc ion based on a cinnamyl pyrazoline derivative and its imaging in live cells

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Abstract

A fluorescence probe based on cinnamyl pyrazoline was developed and synthesized. The probe detected Zn2+ ion that was mixed with a series of cations in aqueous ethanol with high selectivity and high sensitivity. After adding Zn2+, the fluorescence intensity was significantly enhanced, with a 56-fold increase. The detection limits and binding constants of 2.95 × 10−8 M and 1.468 × 104 M−1 were calculated by a fluorescence titration experiment. The 1 : 1 binding chemometrics of the 1–Zn2+ complex was analyzed by Job's plot. The probe showed good reversibility when adding PPi. Additionally, the “turn-on” fluorescent probe with excellent membrane permeability was satisfactorily applied to microscopic imaging for the detection of Zn2+ in baby hamster kidney (BHK)-21 cells.

Graphical abstract: A highly selective “turn-on” fluorescent sensor for zinc ion based on a cinnamyl pyrazoline derivative and its imaging in live cells

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Publication details

The article was received on 07 Jan 2018, accepted on 15 Mar 2018 and first published on 17 Mar 2018


Article type: Paper
DOI: 10.1039/C8AY00037A
Citation: Anal. Methods, 2018,10, 1833-1841
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    A highly selective “turn-on” fluorescent sensor for zinc ion based on a cinnamyl pyrazoline derivative and its imaging in live cells

    Y. Yang, C. Ma, Y. Zhang, Q. Xue, J. Ru, X. Liu and H. Guo, Anal. Methods, 2018, 10, 1833
    DOI: 10.1039/C8AY00037A

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