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Effects of electrode insertion depth on neural signal amplitude in the spinal cord

Abstract

The technique used for electrode insertion navigation is of crucial importance for neural signal collection. The spinal cord mapping method tracks the placement of electrodes throughout their insertion trajectory in vivo, allowing high accuracy for electrode insertion guidance with micrometer step resolution, but is time consuming. In the present study, we used the spinal cord mapping method to collect pain signals from the rat spinal cord. We found that the amplitude of the neural signal was approximately inversely proportional to the electrode insertion depth when the electrode was more than 30 µm away from the target neurons, and was approximately proportional to the square of the electrode insertion depth when they were close to the target neurons. Based on this relationship, the amplitude of the collected neural signal can be used to determine electrode placement to reduce time consumption for electrode positioning.

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Publication details

The article was received on 05 Jan 2018, accepted on 12 Feb 2018 and first published on 12 Feb 2018


Article type: Paper
DOI: 10.1039/C8AY00028J
Citation: Anal. Methods, 2018, Accepted Manuscript
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    Effects of electrode insertion depth on neural signal amplitude in the spinal cord

    S. Deng, H. Hu and P. Wang, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C8AY00028J

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