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Issue 12, 2018
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Adsorptive stripping voltammetric determination of dicyclomine hydrochloride at a glassy carbon electrode modified with silver decorated Fe3O4 nanocubes in pharmaceutical and biological samples

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Abstract

The proposed work introduces an electrochemical sensor based on an Fe3O4/Ag nanocomposite for highly sensitive and selective electrochemical determination of dicyclomine hydrochloride (DcCl) using adsorptive stripping square wave voltammetry (AdSSWV). A nanocomposite of silver decorated Fe3O4 nanocubes has been synthesized using a facile sonochemical method. The prepared nanocomposite was characterized using various characterization techniques. The impact of various parameters such as pH, scan rate, accumulation potential and accumulation time on peak current was studied employing different techniques including differential pulse voltammetry (DPV), cyclic voltammetry (CV) and AdSSWV. Under the optimized conditions, the peak current is found to be linearly proportional to the DcCl concentration in a wide linear working range from 2.0 × 10−7 to 8.0 × 10−4 M with a limit of detection (LOD) and a limit of quantification (LOQ) of 4.8 × 10−9 M and 1.6 × 10−8 M, respectively. The fabricated sensor exhibited high sensitivity and selectivity along with good stability and reproducibility, and therefore the proposed method can serve as an excellent platform for the determination of DcCl at the nanomolar level with adequate recovery in pharmaceutical as well as biological samples.

Graphical abstract: Adsorptive stripping voltammetric determination of dicyclomine hydrochloride at a glassy carbon electrode modified with silver decorated Fe3O4 nanocubes in pharmaceutical and biological samples

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Publication details

The article was received on 02 Jan 2018, accepted on 10 Feb 2018 and first published on 13 Feb 2018


Article type: Paper
DOI: 10.1039/C8AY00009C
Citation: Anal. Methods, 2018,10, 1441-1451
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    Adsorptive stripping voltammetric determination of dicyclomine hydrochloride at a glassy carbon electrode modified with silver decorated Fe3O4 nanocubes in pharmaceutical and biological samples

    C. R. Rawool, A. S. Rajpurohit, N. S. Punde and A. K. Srivastava, Anal. Methods, 2018, 10, 1441
    DOI: 10.1039/C8AY00009C

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