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Quantification of Cocaine and its Adulterants by Nuclear Magnetic Resonance Spectroscopy without Deuterated Solvent (No-D qNMR)

Abstract

In this study, a new method was developed to quantify cocaine and some adulterants (lidocaine, caffeine, phenacetin, procaine and benzocaine) using the nuclear magnetic resonance spectroscopy without the use of deuterated solvents (No-D qNMR). The No-D qNMR presents as main advantages: low cost (in comparison to the use of deuterated solvents), non-destructive and speed analysis, and able to detect non-volatile compounds. For the analytical validation achievement, figures of merit such as selectivity and specificity, linearity, quantification limit, detection limit, accuracy, precision and robustness were obtained. The built models presented excellent precision (< 5%), linearity (>0.99), and LOD values which varied between 0.126 and 0.666 mg mL-1. With the purpose to verify the models’ predictive capacity, 34 crack samples seized by the Civil Police of Espírito Santo State – Brazil were analyzed, and the average cocaine content found was around 17.5 wt%, which is in line with expectations (up to approximately 30 wt%). Moreover, 50 wt% of the samples contained phenacetin, 9 wt% caffeine, 3 wt% procaine and lidocaine, while benzocaine wasn’t identified.

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Publication details

The article was received on 31 Dec 2017, accepted on 30 Jan 2018 and first published on 30 Jan 2018


Article type: Paper
DOI: 10.1039/C7AY03000B
Citation: Anal. Methods, 2018, Accepted Manuscript
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    Quantification of Cocaine and its Adulterants by Nuclear Magnetic Resonance Spectroscopy without Deuterated Solvent (No-D qNMR)

    W. Romão, W. Rocha, J. Almeida, R. M. Correia, F. Tosato, N. Madeira, P. R. Filgueiras, V. Lacerda Jr., J. C.C. Freitas and A. C. Neto, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C7AY03000B

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