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Issue 5, 2018
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Electrochemical immunosensor detection of tumor markers based on a GO composite nanoprobe for signal amplification

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Abstract

A novel strategy based on nanoprobes for signal amplification was introduced in an electrochemical immunoassay platform. The nanoprobes based on poly(2-hydroxyethyl methacrylate)-r-poly(acrylic acid) (PHEMA-r-PAA) and graphene oxide (GO) have the effect of double signal amplification. The resulting sandwich-type electrochemical immunosensor was able to detect the tumor marker alpha fetal protein (AFP) with high sensitivity and high selectivity. A good linear relationship could be observed in the AFP concentration range of 3.5 pg mL−1 to 35 ng mL−1 (R2 = 0.9898), and the minimum detection limit was 0.106 pg mL−1. In addition, the electrochemical immunosensor exhibited good stability and could be applied to AFP detection in clinical serum.

Graphical abstract: Electrochemical immunosensor detection of tumor markers based on a GO composite nanoprobe for signal amplification

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Publication details

The article was received on 20 Dec 2017, accepted on 01 Jan 2018 and first published on 02 Jan 2018


Article type: Paper
DOI: 10.1039/C7AY02932B
Citation: Anal. Methods, 2018,10, 526-532
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    Electrochemical immunosensor detection of tumor markers based on a GO composite nanoprobe for signal amplification

    J. Wang, D. Yang, M. Chen, B. Liu, H. Chen, H. Xu, W. Wang and L. Bai, Anal. Methods, 2018, 10, 526
    DOI: 10.1039/C7AY02932B

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