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Electrochemical Immunosensor Detection of Tumor Markers based on GO Composite Nanoprobe for Signal Amplification

Abstract

A novel strategy based on nanoprobes for signal amplification was introduced in electrochemical immunoassay platform. The nanoprobes based on poly(2-hydroxyethyl methacrylate)-r-poly(acrylic acid) (PHEMA-r-PAA) and graphene oxide (GO) have the effect of double signal amplification. The resulting sandwich-type electrochemical immunosensor was able to detect tumor markers alpha fetal protein (AFP) with high sensitivity and high selectivity. A good linear relationship showed in the range of AFP concentration with 3.5 pg/mL ~ 35 ng/mL (R2 = 0.9898), and the minimum detection limit was 0.106 pg/mL. In addition, the electrochemical immunosensor exhibited good stability and could be applied to AFP detection in clinical serum.

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Publication details

The article was accepted on 01 Jan 2018 and first published on 02 Jan 2018


Article type: Paper
DOI: 10.1039/C7AY02932B
Citation: Anal. Methods, 2018, Accepted Manuscript
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    Electrochemical Immunosensor Detection of Tumor Markers based on GO Composite Nanoprobe for Signal Amplification

    J. Wang, D. Yang, M. Chen, B. Liu, H. Chen, H. Xu, W. Wang and L. Bai, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C7AY02932B

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