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A “turn-on” fluorescence sensor for ascorbic acid based on graphene quantum dots via fluorescence resonance energy transfer

Abstract

A novel turn-on fluorescent sensor for the detection of ascorbic acid (AA) has been developed based on fluorescence resonance energy transfer (FRET) between graphene quantum dots (GQDs) and squaric acid (SQA)-iron(III). In this assay, iron(III) can rapidly coordinate with the SQA to produce SQA-iron(III). The absorbance band of SQA-iron(III) could be largely overlapped with the emission band of GQDs, thus resulting the fluorescence resonance energy transfer (FRET)-induced fluorescence quenching of GQDs. Moreover, the fluorescence of GQDs can be sensitively turned on by AA through the oxidation-reduction between iron(III) and AA. Because the absorbance of the solution reduced and thus the FRET decreased after the transformation of SQA-iron(III) into SQA-iron(II). This FRET-based nanosensor shows high selective and sensitive response in the concentration of AA ranging from 1.0-95 μM with the detection limit as lower as 200 nM, which is lower than other fluorescent assays. Finally, the proposed sensing system was successfully applied to direct analysis of AA in real samples with satisfactory results.

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Publication details

The article was received on 07 Dec 2017, accepted on 10 Jan 2018 and first published on 11 Jan 2018


Article type: Paper
DOI: 10.1039/C7AY02828H
Citation: Anal. Methods, 2018, Accepted Manuscript
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    A “turn-on” fluorescence sensor for ascorbic acid based on graphene quantum dots via fluorescence resonance energy transfer

    Y. Gao, X. Yan, M. Li, H. Gao, J. Sun, S. Zhu, S. Han, L. Jia, X. Zhao and H. Wang, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C7AY02828H

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