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Effect of mobile phase composition on the analysis of aggregates of antibody drug conjugates (ADCs) using size exclusion chromatography

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Abstract

In this study, the effect of mobile phase composition for size exclusion chromatography (SEC) on antibody drug conjugate (ADC) aggregate analysis was investigated. The use of organic components as well as high ionic strength during aggregate analysis was demonstrated to be advantageous.

Graphical abstract: Effect of mobile phase composition on the analysis of aggregates of antibody drug conjugates (ADCs) using size exclusion chromatography

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Publication details

The article was received on 21 Nov 2017, accepted on 13 Dec 2017 and first published on 14 Dec 2017


Article type: Communication
DOI: 10.1039/C7AY02696J
Citation: Anal. Methods, 2018, Advance Article
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    Effect of mobile phase composition on the analysis of aggregates of antibody drug conjugates (ADCs) using size exclusion chromatography

    R. Neupane, M. Källsten, F. Lehmann and J. Bergquist, Anal. Methods, 2018, Advance Article , DOI: 10.1039/C7AY02696J

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