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Issue 10, 2018
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Simultaneous determination of fifteen toxic alkaloids in meat dishes and vegetable dishes using double layer pipette tip magnetic dispersive solid phase extraction followed by UFLC-MS/MS

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Abstract

A novel double layer pipette tip magnetic dispersive solid phase extraction (DPT-MSPE) based on polyamidoamine-functionalized magnetic carbon nanotubes (PAMAM@Mag-CNTs) was developed for the purification of fifteen toxic alkaloids in meat dishes and vegetable dishes. PAMAM@Mag-CNTs were synthesized through direct reaction between the carboxy group on the surface of the Mag-CNTs and the peripheral amino group of the polyamidoamine (PAMAM) dendrimers. The magnetism of PAMAM@Mag-CNTs simplified the post-processing during preparation of the sorbent, and reinforced the interaction between the sorbents and the analytes during the cleanup procedure. An ultra-fast liquid chromatography-tandem quadrupole mass spectrometry (UFLC-MS/MS) coupled with DPT-MSPE method has been developed to determine fifteen alkaloids in meat dishes and vegetable dishes. Under the optimal conditions, satisfactory recoveries, i.e., 83.4–125% for meat dishes and 84.2–122% for vegetable dishes, were obtained due to the high cleanup efficiency of the DPT-MSPE. Furthermore, the method, which displays good linearity (r ≥ 0.9991), acceptable precision (RSD < 8%), and low limits of quantification (0.054–1.058 ng g−1), has been successfully applied to several food samples, and it was confirmed that PAMAM@Mag-CNTs DPT-MSPE was a highly effective extraction method for alkaloids in cooked food samples.

Graphical abstract: Simultaneous determination of fifteen toxic alkaloids in meat dishes and vegetable dishes using double layer pipette tip magnetic dispersive solid phase extraction followed by UFLC-MS/MS

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Publication details

The article was received on 08 Nov 2017, accepted on 08 Feb 2018 and first published on 09 Feb 2018


Article type: Paper
DOI: 10.1039/C7AY02608K
Citation: Anal. Methods, 2018,10, 1151-1162
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    Simultaneous determination of fifteen toxic alkaloids in meat dishes and vegetable dishes using double layer pipette tip magnetic dispersive solid phase extraction followed by UFLC-MS/MS

    H. Cheng, F. Wang, Y. Zhao, Y. Zhang, M. Jin and Y. Zhu, Anal. Methods, 2018, 10, 1151
    DOI: 10.1039/C7AY02608K

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