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Enhanced electrochemiluminescence of luminol by in situ silver nanoparticles decorated graphene dot for glucose analysis

Abstract

A rapid, linker free, single-step strategy for in situ synthesis of graphene quantum dot-Luminol-Ag nanoparticle (GQD-Luminol-AgNPs) nano-composites was designed by reducing AgNO3 with electrochemiluminescent reagent luminol in the presence of GQD. The nano-composites were characterized using transmission electron microscopy, UV-Vis absorption spectra and EDS pattern. The results indicated that many Ag nanoparticles (AgNPs) with an average diameter of about 5 nm were dispersed uniformly on the surface of GQD nanosheets. Luminol molecules were also decorated on the nano-composites surface. Thus, the nano composites showed excellent electrochemiluminescence (ECL) activity in presence of H2O2. In order to build a glucose ECL-based biosensor, the prepared sensor was also modified with glucose oxidase (GOx). GOx enzyme was covalently immobilized on GQD-Luminol-AgNPs modified glassy carbon electrode. The designed ECL biosensor showed great performance toward glucose detection in a concentration range between 25 and 250 μM with a satisfactory detection limit (8 μM).

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Publication details

The article was received on 08 Oct 2017, accepted on 20 Dec 2017 and first published on 03 Jan 2018


Article type: Paper
DOI: 10.1039/C7AY02375H
Citation: Anal. Methods, 2018, Accepted Manuscript
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    Enhanced electrochemiluminescence of luminol by in situ silver nanoparticles decorated graphene dot for glucose analysis

    F. Salehnia, M. Hosseini and M. R. Ganjali, Anal. Methods, 2018, Accepted Manuscript , DOI: 10.1039/C7AY02375H

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