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Design synthesis of controllable flower-like Pt-graphene oxide architecture through electrostatic self-assembly for DNA damage biomarker-8-Hydroxy-2′-deoxyguanosine biosensing research

Abstract

Controllable flower-like Pt-graphene oxide (PtNFs-GO) architecture was synthesized through layer-layer electrostatic self-assembly. Hexadecyltrimethylammonium chloride (CTAC) micelle was employed as template and Pt nanoflowers with different size were selectively synthesized by controlling the dissolved K2PtCl4 precursor and CTAC amounts in the reaction system. The prepared PtNFs-GO was applied for DNA damage biomarker-8-hydroxy-2'-deoxyguanosine (8-OHdG) biosensing research. With the distinctive flower-like morphology of PtNFs and high electrical conductivity of GO, the PtNFs-GO architecture shows excellent electrochemical biosensing performance towards the oxidation of 8-OHdG. The very low detection limit of 0.025 nM is obtained. Moreover, the fabricated PtNFs-GO was used for the detection of 8-OHdG generated from damaged DNA sample, which can be used to evaluate and confirm the mechanism of DNA damage, it is of great importance in gene diagnosis, clinical and life sciences.

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Publication details

The article was received on 16 Apr 2018, accepted on 07 Jun 2018 and first published on 09 Jun 2018


Article type: Paper
DOI: 10.1039/C8AN00698A
Citation: Analyst, 2018, Accepted Manuscript
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    Design synthesis of controllable flower-like Pt-graphene oxide architecture through electrostatic self-assembly for DNA damage biomarker-8-Hydroxy-2′-deoxyguanosine biosensing research

    Q. Zhao, Q. Zhang, Y. Sun, Y. Liu, H. Lu, X. Fan, H. Wang, Y. Zhang and H. Wang, Analyst, 2018, Accepted Manuscript , DOI: 10.1039/C8AN00698A

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