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Issue 12, 2018
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Small molecule–protein interactions in branch migration thermodynamics: modelling and application in the homogeneous detection of proteins and small molecules

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Abstract

We have disclosed the unique inhibition effect of small molecule–protein interactions toward the DNA branch migration process and constructed a complete thermodynamic model for it. The disclosed effect was further coupled with the steric hindrance effect to establish a homogeneous assay for proteins and small molecules with ultra-high inhibition factors and sensitivity.

Graphical abstract: Small molecule–protein interactions in branch migration thermodynamics: modelling and application in the homogeneous detection of proteins and small molecules

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Publication details

The article was received on 24 Mar 2018, accepted on 13 May 2018 and first published on 14 May 2018


Article type: Communication
DOI: 10.1039/C8AN00555A
Citation: Analyst, 2018,143, 2755-2759
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    Small molecule–protein interactions in branch migration thermodynamics: modelling and application in the homogeneous detection of proteins and small molecules

    X. Zhou, Z. Cui, L. Liu, Z. Sun, M. Lin, Q. Hu, H. Wang and X. Xiao, Analyst, 2018, 143, 2755
    DOI: 10.1039/C8AN00555A

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