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Small molecule-protein interactions in branch migration thermodynamics: modelling and application in homogeneous detection of proteins and small molecules

Abstract

We have disclosed the unique inhibition effect of small moleculeprotein interactions toward DNA branch migration process and constructed a complete thermodynamic model for it. The disclosed effect was further coupled with steric hindrance effect to establish a homogenous assay for proteins and small molecules with ultra-high inhibition factors and sensitivity.

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Publication details

The article was received on 24 Mar 2018, accepted on 13 May 2018 and first published on 14 May 2018


Article type: Communication
DOI: 10.1039/C8AN00555A
Citation: Analyst, 2018, Accepted Manuscript
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    Small molecule-protein interactions in branch migration thermodynamics: modelling and application in homogeneous detection of proteins and small molecules

    X. Zhou, Z. Cui, L. Liu, Z. Sun, M. Lin, Q. Hu, H. Wang and X. Xiao, Analyst, 2018, Accepted Manuscript , DOI: 10.1039/C8AN00555A

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