Issue 12, 2018

Small molecule–protein interactions in branch migration thermodynamics: modelling and application in the homogeneous detection of proteins and small molecules

Abstract

We have disclosed the unique inhibition effect of small molecule–protein interactions toward the DNA branch migration process and constructed a complete thermodynamic model for it. The disclosed effect was further coupled with the steric hindrance effect to establish a homogeneous assay for proteins and small molecules with ultra-high inhibition factors and sensitivity.

Graphical abstract: Small molecule–protein interactions in branch migration thermodynamics: modelling and application in the homogeneous detection of proteins and small molecules

Supplementary files

Article information

Article type
Communication
Submitted
24 Mar 2018
Accepted
13 May 2018
First published
14 May 2018

Analyst, 2018,143, 2755-2759

Small molecule–protein interactions in branch migration thermodynamics: modelling and application in the homogeneous detection of proteins and small molecules

X. Zhou, Z. Cui, L. Liu, Z. Sun, M. Lin, Q. Hu, H. Wang and X. Xiao, Analyst, 2018, 143, 2755 DOI: 10.1039/C8AN00555A

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