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Channel current analysis estimates the pore-formation and the penetration of transmembrane peptides

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Abstract

We measured the current signal of the transmembrane model peptides using the barrel-stave, toroidal pore, and penetration models in order to establish a precise assignment of the channel signals. In addition, we analyzed the spike signals to estimate the membrane penetration of model cell-penetration peptides of different lengths.

Graphical abstract: Channel current analysis estimates the pore-formation and the penetration of transmembrane peptides

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Publication details

The article was received on 07 Feb 2018, accepted on 28 Apr 2018 and first published on 02 May 2018


Article type: Communication
DOI: 10.1039/C8AN00243F
Citation: Analyst, 2018, Advance Article
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    Channel current analysis estimates the pore-formation and the penetration of transmembrane peptides

    Y. Sekiya, S. Sakashita, K. Shimizu, K. Usui and R. Kawano, Analyst, 2018, Advance Article , DOI: 10.1039/C8AN00243F

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