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Issue 15, 2018
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Label-free tracking of nanosized graphene oxide cellular uptake by confocal Raman microscopy

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Abstract

Graphene oxide (GO), a partially oxidized two-dimensional allotrope of carbon, is an attractive nanocarrier for cancer diagnostics and therapy. The nanometer-sized GO is known to permeate cell membranes. Herein we studied the cellular uptake pathways of GO nanoflakes by cancer and non-cancerous cell lines. By employing confocal Raman imaging, we were able to track the GO cellular uptake in living cells (C33 and MDCK) without any additional fluorescent or plasmonic labels. This specific progress in label-free Raman imaging of GO facilitates the monitoring of nanoflakes at the cellular level.

Graphical abstract: Label-free tracking of nanosized graphene oxide cellular uptake by confocal Raman microscopy

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Publication details

The article was received on 05 Feb 2018, accepted on 12 Jun 2018 and first published on 12 Jun 2018


Article type: Paper
DOI: 10.1039/C8AN00225H
Citation: Analyst, 2018,143, 3686-3692
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    Label-free tracking of nanosized graphene oxide cellular uptake by confocal Raman microscopy

    M. Eliášová Sohová, M. Bodík, P. Siffalovic, N. Bugárová, M. Labudová, M. Zaťovičová, T. Hianik, M. Omastová, E. Majková, M. Jergel and S. Pastoreková, Analyst, 2018, 143, 3686
    DOI: 10.1039/C8AN00225H

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