Jump to main content
Jump to site search

An early investigative serum Raman spectroscopy study of meningioma


Meningiomas represent the most frequently reported non-glial, primary brain and central nervous system (CNS) tumors. Meningiomas often display a spectrum of anomalous locations and morphological attributes, deterring their timely diagnosis. The majority of them are sporadic in nature and thus the present-day screening strategies, including radiological investigations, often result in misdiagnosis due to their aberrant and equivocal radiological facets. Therefore, it is pertinent to explore less invasive and patient-friendly biofluids such as serum for their screening and diagnostics. The utility of serum Raman spectroscopy in diagnosis and therapeutic monitoring of cancers has been reported in the literature. In the present study, for the first time, to the best of our knowledge, we have explored Raman spectroscopy to classify sera of meningioma and control subjects. For this exploration, 35 each of meningioma and control subjects were accrued and spectra revealed variance in the levels of DNA, proteins, lipids, amino acids and β-carotene, i.e., relatively higher protein, DNA and lipid content in meningioma. Subsequent Principal Component Analysis (PCA) and Principal Component-Linear Discriminant Analysis (PC-LDA) followed by Leave-One-Out Cross-Validation (LOOCV) and limited independent test data, in patient-wise approach, yielded classification efficiency of 92 and 80% for healthy and meningioma, respectively. Additionally, in the analogous analysis of healthy and different grades of meningioma, similar results were obtained. These results indicate the potential of Raman spectroscopy in differentiating meningioma. As present methods suffer from known limitations, with the prospective validation, on a larger cohort, serum Raman spectroscopy could be a adjuvant/alternative approach in the clinical management of meningioma.

Back to tab navigation

Publication details

The article was accepted on 26 Feb 2018 and first published on 05 Mar 2018

Article type: Paper
DOI: 10.1039/C8AN00224J
Citation: Analyst, 2018, Accepted Manuscript
  •   Request permissions

    An early investigative serum Raman spectroscopy study of meningioma

    K. Mehta, A. Atak, A. Sahu, S. Srivastava and M. K. Chilakapati, Analyst, 2018, Accepted Manuscript , DOI: 10.1039/C8AN00224J

Search articles by author