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Voltammetric Method for Fe (III) in Blood Serum using Screen Printed Electrode modified with a Schiff Base ionophore

Abstract

A potent electrochemical ionophore (SMS-2) based on Schiff base has been used for the modification of screen printed electrode (SPE). The modified disposable electrode can selectively detect ferric ions in aqueous medium. Redox behavior of the proposed strip was characterized by using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Incorporation of the ligand in the ink of the SPE enhanced the analytical performance of the electrode and surface modification was confirmed by SEM and EDX analysis. Shifting/quenching of cathodic peak potential of the ionophore after binding with Fe (III) ions was used to detect and measure ferric ion concentration. This sensor can identify Fe (III) in the detection range of 0.625 µM to 7.5 µM. The modified SPE can selectively detect ferric ions in the presence of many other interfering ions. Modified SPE was successfully used to determine Fe (III) content in the blood serum samples. Metal-ionophore complex structure was optimized by DFT to study the energetics of the metal-ionophore interactions.

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Publication details

The article was received on 29 Jan 2018, accepted on 05 May 2018 and first published on 07 May 2018


Article type: Paper
DOI: 10.1039/C8AN00174J
Citation: Analyst, 2018, Accepted Manuscript
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    Voltammetric Method for Fe (III) in Blood Serum using Screen Printed Electrode modified with a Schiff Base ionophore

    S. K. Mittal, S. Rana, N. Kaur and C. E. Banks, Analyst, 2018, Accepted Manuscript , DOI: 10.1039/C8AN00174J

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