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Issue 4, 2018
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Identification of isoforms of aspartic acid residues in peptides by 2D UV-MS fingerprinting of cold ions

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Abstract

We use 2D UV-MS cold-ion spectroscopy for the identification of L-Asp, D-Asp, L-isoAsp and D-isoAsp residues in a fragment peptide derived from the hormone protein amylin. Relative solution concentrations of all four isoforms in an equimolar quaternary mixture have been determined within 4% error. This method demonstrates that for binary mixtures of the peptides an accuracy of 2.5% can be reached in few-second measurements.

Graphical abstract: Identification of isoforms of aspartic acid residues in peptides by 2D UV-MS fingerprinting of cold ions

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Publication details

The article was received on 18 Dec 2017, accepted on 12 Jan 2018 and first published on 12 Jan 2018


Article type: Communication
DOI: 10.1039/C7AN02044A
Citation: Analyst, 2018,143, 833-836
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    Identification of isoforms of aspartic acid residues in peptides by 2D UV-MS fingerprinting of cold ions

    V. Kopysov, M. V. Gorshkov and O. V. Boyarkin, Analyst, 2018, 143, 833
    DOI: 10.1039/C7AN02044A

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