Jump to main content
Jump to site search

Recent advances in microRNA detection


Development of the simple, robust, and reliable microRNA (miRNA) detection methods are of great significance to the studies of miRNAs’ biological function, the molecular diagnostics, the treatment of diseases, and the targeted drugs. In recent years, with the increasing development of miRNA research, lots of novel approaches were developed for the detection of miRNA in terms of sensitivity, specificity, multiplicity, and imaging in situ, etc. Especially, nucleic acid amplification-based methods and many of detection techniques such as droplet digital PCR (ddPCR), electrochemiluminescence (ECL), surface-enhanced Raman spectroscopy (SERS), and mass spectrometry (MS) have been employed widely for highly sensitive detection of miRNA. The new progresses in miRNA detection have accelerated the miRNA functional researches, and clinical diagnostics. In this review, we summarize the recent progress in the development of miRNA detection methods and new applications. This review will provide guidelines for the development of more advanced miRNA detection methods with high sensitivity and specificity, and applicability to biochemical researches, disease diagnosis and therapy.

Back to tab navigation

Publication details

The article was received on 11 Dec 2017, accepted on 20 Feb 2018 and first published on 01 Mar 2018

Article type: Critical Review
DOI: 10.1039/C7AN02001E
Citation: Analyst, 2018, Accepted Manuscript
  •   Request permissions

    Recent advances in microRNA detection

    Y. Cheng, L. Dong, J. Zhang, Y. Zhao and Z. Li, Analyst, 2018, Accepted Manuscript , DOI: 10.1039/C7AN02001E

Search articles by author