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Issue 5, 2018
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A turn-on near-infrared fluorescence probe with aggregation-induced emission based on dibenzo[a,c]phenazine for detection of superoxide anions and its application in cell imaging

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Abstract

A new turn-on near-infrared fluorescence probe (BDP) based on dibenzo[a,c]phenazine for superoxide anion detection with aggregation-induced emission properties as well as a desirable large Stokes shift was designed and synthesized. After BDP reacted with superoxide, the initial diphenyl-phosphinyl groups of BDP were cleaved, resulting in the production of the pyridinium modified fluorophore (BD) with near-infrared emission. The fluorescent sensor BDP has a high selectivity for superoxide anions over some other intracellular ROSs, reductants, metal ions and amino acids. When HepG2 cells undergo apoptosis and inflammation, BDP is a good probe to keep track of the endogenous superoxide anion level by confocal laser scanning microscopic imaging.

Graphical abstract: A turn-on near-infrared fluorescence probe with aggregation-induced emission based on dibenzo[a,c]phenazine for detection of superoxide anions and its application in cell imaging

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Publication details

The article was received on 16 Nov 2017, accepted on 15 Jan 2018 and first published on 16 Jan 2018


Article type: Paper
DOI: 10.1039/C7AN01860F
Citation: Analyst, 2018,143, 1242-1249
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    A turn-on near-infrared fluorescence probe with aggregation-induced emission based on dibenzo[a,c]phenazine for detection of superoxide anions and its application in cell imaging

    J. Yang, X. Liu, H. Wang, H. Tan, X. Xie, X. Zhang, C. Liu, X. Qu and J. Hua, Analyst, 2018, 143, 1242
    DOI: 10.1039/C7AN01860F

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