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Piezo-Ring-on-Chip Microfluidic Device for Simple and Low-Cost Mass Spectrometry Interfacing

Abstract

Mass spectrometry (MS) interfacing technology provides the capability for incorporating microfluidic processing with post MS analysis. In this study, we propose a simple piezo-ring-on-chip microfluidic device for the controlled spraying of MALDI-MS targets. This device uses a low-cost, commercially-available ring-shaped piezoelectric acoustic atomizer (piezo-ring) directly integrated into a polydimethylsiloxane microfluidic device to spray the sample onto the MS target substrate. The piezo-ring-on-chip microfluidic device’s design, fabrication, actuation, and its pulsatile pumping effects were evaluated. The spraying performance was examined by depositing organic matrix samples to the MS target substrate by both an automatic linear motion motor, and manual deposition. Matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) was performed to analyze the peptide samples on the MALDI target substrates. Using our technique, model peptides with 10-6M concentration can be successfully detected. Results also indicate that the piezo-ring-on-chip approach forms finer matrix crystalline and presents better MS signal uniformity with little sample consumption compared to the conventional pipetting method.

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Supplementary files

Publication details

The article was received on 17 Sep 2017, accepted on 30 Dec 2017 and first published on 05 Jan 2018


Article type: Paper
DOI: 10.1039/C7AN01548H
Citation: Analyst, 2018, Accepted Manuscript
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    Piezo-Ring-on-Chip Microfluidic Device for Simple and Low-Cost Mass Spectrometry Interfacing

    C. Tsao, I. Lei, P. Chen and Y. Yang, Analyst, 2018, Accepted Manuscript , DOI: 10.1039/C7AN01548H

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