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Identification of the Al-binding proteins that account for aluminum neurotoxicity and transport in vivo

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Abstract

Studies have shown that aluminum (Al) is the most abundant neurotoxic element on Earth, and is implicated in the pathogenesis of Alzheimer's disease (AD). However, the mechanisms underlying Al-induced neurotoxicity are still largely elusive. Based on affinity analyses with Al and LC-LTQ-MS, we have found that serum albumin, brain CK-B and 14-3-3ζ protein have a high affinity for Al3+, and albumin has a much stronger affinity for Al than transferrin. The normal activity of CK-B, and physiological combination of 14-3-3ζ with tau can be severely perturbed by Al. We anticipate that our assay will provide a new focus concerning the mechanism underlying Al-induced neurotoxicity, and aid the design of strategies to prevent AD and other human diseases related to Al overload.

Graphical abstract: Identification of the Al-binding proteins that account for aluminum neurotoxicity and transport in vivo

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Publication details

The article was received on 01 Oct 2017, accepted on 22 Nov 2017 and first published on 01 Dec 2017


Article type: Paper
DOI: 10.1039/C7TX00261K
Citation: Toxicol. Res., 2018, Advance Article
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    Identification of the Al-binding proteins that account for aluminum neurotoxicity and transport in vivo

    D. Cheng, X. Wang, Y. Xi, J. Cao and W. Jiang, Toxicol. Res., 2018, Advance Article , DOI: 10.1039/C7TX00261K

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