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Bifenthrin induced neurotoxicity in rats: Involvement of oxidative stress

Abstract

Extensive usage of synthetic pyrethroids has resulted in serious human health issues. Induction of oxidative stress is an important mechanism of action of most pesticides including pyrethroids. The present study intends to elucidate the possible role of oxidative stress in bifenthrin induced neurotoxicity. Adult male Wistar rats were administered bifenthrin (3.5 and 7mg/kg body weight p.o.) for 30 days. Behavioral studies were conducted on a set of randomly selected rats from each treatment group after completion of treatment. Neurochemical parameters were assessed 24h after the last dose administration. The selected behavioral and neurochemical endpoints were also assessed 15 days after cessation of exposure to reveal whether the neurobehavioral changes produced by bifenthrin were temporary or permanent. Deficits in motor activity, motor incoordination and cognitive impairment were observed following exposure to bifenthrin. Levels of biogenic amines viz. dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), epinephrine (EPN), nor epinephrine (NE), serotonin (5-HT) were altered in frontal cortex, corpus striatum and hippocampus of bifenthrin treated rats. A decrease in the activity of acetylcholinesterase (AChE) occurred in all the regions of the brain. Both the doses of bifenthrin significantly induced lipid peroxidation (LPO) and increased the protein carbonyl levels in frontal cortex, corpus striatum and hippocampus of rats. Activities of antioxidant enzymes viz. catalase, superoxide dismutase and glutathione peroxidase were also suppressed in all selected regions of the brain. A trend of recovery was however observed in all the behavioral and neurochemical endpoints 15 days following withdrawal of exposure. Oxidative stress seems to play an important role in bifenthrin induced neurotoxicity. Our study suggests that long term exposure to these compounds can produce detrimental effects.

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Publication details

The article was received on 23 Jul 2017, accepted on 04 Oct 2017 and first published on 12 Oct 2017


Article type: Paper
DOI: 10.1039/C7TX00205J
Citation: Toxicol. Res., 2017, Accepted Manuscript
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    Bifenthrin induced neurotoxicity in rats: Involvement of oxidative stress

    F. Syed, K. K. Awasthi, L. P. Chandravanshi, R. Verma, N. K. Rajawat, V. K. Khanna, J. J. P and I. Soni, Toxicol. Res., 2017, Accepted Manuscript , DOI: 10.1039/C7TX00205J

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