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Issue 6, 2017
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Toxicological effects of patulin mycotoxin on the mammalian system: an overview

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Abstract

The mycotoxin PAT (4-hydroxy-4H-furo[3,2c]pyran-2[6H]-one) is a secondary metabolic product of molds such as Penicillium, Aspergillus, and Byssochlamys species. PAT is a common contaminant of fruit and vegetable based products, most notably apples. Despite PAT's original discovery as an antibiotic, it has come under heavy scrutiny for its potential to impart negative health effects. Studies investigating these health effects have proved its toxic potential. PAT occurrence in the food commodities poses a serious threat and necessitates novel and cost-effective mitigation methods to remove it from food products. It also creates a demand to improve handling and food processing techniques. With this being the case, several studies have been devoted to understanding the key biological and chemical attributes of PAT. While past research has elucidated a great deal, PAT contamination continues to be a challenge for the food industry. Here, we review its influence within the mammalian system, including its regulation, incidences of experimental evidence of PAT toxicity, its interaction with intracellular components, and the effects of PAT induced systemic toxicity on vital organs. Finally, key areas where future PAT research should focus to best control the PAT contamination problem within the food industry have been addressed.

Graphical abstract: Toxicological effects of patulin mycotoxin on the mammalian system: an overview

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Publication details

The article was received on 18 May 2017, accepted on 09 Aug 2017 and first published on 09 Aug 2017


Article type: Review Article
DOI: 10.1039/C7TX00138J
Citation: Toxicol. Res., 2017,6, 764-771
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    Toxicological effects of patulin mycotoxin on the mammalian system: an overview

    S. Pal, N. Singh and K. M. Ansari, Toxicol. Res., 2017, 6, 764
    DOI: 10.1039/C7TX00138J

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