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Comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes toxicity

Abstract

Octahedral rhenium cluster compound Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] has recently emerged as a very promising X-ray contrast agent for biomedical applications. However, the synthesis of this compound is rather challenging due to difficulty to control the hydrolysis of initial P(C2H4CN)3 ligand during the reaction process. Therefore, in this report we compare the in vitro and in vivo toxicity of Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] with those of related compounds featuring fully hydrolysed form of the phosphine ligand, namely Na2H14[{Re6Q8}(P(C2H4COO)3)6] (Q = S or Se). Our results demonstrate that cytotoxicity and acute in vivo toxicity of the complex Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6] solutions were considerably lower than those of compounds with fully hydrolysed ligand P(C2H4COOH)3. Such behavior can be explained by the higher osmolality of Na2H14[{Re6Q8}(P(C2H4COO)3)6] versus Na2H8[{Re6Se8}(P(C2H4CONH2)(C2H4COO)2)6].

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Publication details

The article was received on 24 Mar 2017, accepted on 16 May 2017 and first published on 17 May 2017


Article type: Paper
DOI: 10.1039/C7TX00083A
Citation: Toxicol. Res., 2017, Accepted Manuscript
  • Open access: Creative Commons BY-NC license
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    Comparative study of hydrophilic phosphine hexanuclear rhenium cluster complexes toxicity

    A. A. Krasilnikova, A. O. Solovieva, A. A. Ivanov, K. Brylev, T. Pozmogova, M. A. Gulyaeva, O. G. Kurskaya, A. Y. Alekseev, A. M. Shestopalov, L. V. Shestopalova, A. F. Poveshchenko, O. A. Efremova, Y. V. Mironov and M. A. Shestopalov, Toxicol. Res., 2017, Accepted Manuscript , DOI: 10.1039/C7TX00083A

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