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Silver ions-induced mitochondrial dysfunction via a nonspecific pathway

Abstract

Silver, once regarded as safe noble metal to humans, has been widely used in industrial and commercial products, especially in nanometer biomaterials. It is now well known that Ag+ is biologically active and is able to interact with cell membrane, proteins and DNA. However, very little is understood about the potential impacts of Ag+ at a sub-cellular level. Our work investigated the potential toxicity of Ag+ on mitochondria isolated from rat livers by examining mitochondrial morphology, respiration, swelling, membrane fluidity and reactive oxygen species (ROS) generation. We observed that Ag+ significantly affects mitochondrial structure and function, including mitochondrial swelling, collapse of transmembrane potential, change of permeability and fluidity, decline of respiratory rate, acceleration of ROS, indicating that Ag+ should be seriously regarded as a potentially hazardous substance. Moreover, we concluded that Ag+ injures mitochondrial structure and function by a nonspecific approach, in which the interaction is unregulated by inherent parts such as mitochondria permeability transition pore (MPTP). These results help us learn more about the toxicity of Ag+ at the subcellular (mitochondrial) level and influence future biological and medical application of Ag-based materials.

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Publication details

The article was received on 19 Mar 2017, accepted on 16 May 2017 and first published on 19 May 2017


Article type: Paper
DOI: 10.1039/C7TX00079K
Citation: Toxicol. Res., 2017, Accepted Manuscript
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    Silver ions-induced mitochondrial dysfunction via a nonspecific pathway

    L. Yuan, T. Gao, H. He, F. Jiang and Y. Liu, Toxicol. Res., 2017, Accepted Manuscript , DOI: 10.1039/C7TX00079K

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