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Effect of eriodictyol on preneoplastic lesions, oxidative stress and bacterial enzymes in 1, 2-dimethyl hydrazine-induced colon carcinogenesis

Abstract

Eriodictyol, one of the strong flavonoid extracted from Eriodictyon californicum is known for its antioxidant and anticarcinogenic properties. We have estimated the chemopreventive effect of eriodictyol on 1,2 dimethylhydrazine (DMH) induced experimental colon carcinogenesis in male albino Wistar rats. Rats were randomized into six groups. Our results evaluated the effect of eriodictyol supplementation (200µg/kg b.w.) on DMH (20mg/kg b.w) induced rats, (groups 4 to 6). The incidence of polyps, aberrant crypt foci (ACF) and the lipid peroxidation levels were significantly decreased as compared to DMH-alone treated rats (group 2). In Eriodictyol supplemented DMH-treated rats, we observed increased activity of enzymatic and non-enzymatic antioxidant in circulatory system, liver, and colon. Bacterial enzymes activities of mucosa and fecal were significantly decreased in a treatment of eriodictyol on DMH-induced rats. Moreover, in the eriodictyol supplemented DMH exposed rats, we observed reduced malignant glands of a histopathological appearance of both liver and colon tissue. Further, we also observed reduced AgNORs counts of eriodictyol supplemented to DMH exposed rats. Therefore, we can conclude that eriodictyol could be used as an effective chemopreventive agent against DMH-induced colon carcinogenesis in experimental animal models.

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Publication details

The article was received on 11 Mar 2017, accepted on 16 Jun 2017 and first published on 19 Jun 2017


Article type: Paper
DOI: 10.1039/C7TX00074J
Citation: Toxicol. Res., 2017, Accepted Manuscript
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    Effect of eriodictyol on preneoplastic lesions, oxidative stress and bacterial enzymes in 1, 2-dimethyl hydrazine-induced colon carcinogenesis

    M. Palani, K. Thangaraj and M. VAIYAPURI, Toxicol. Res., 2017, Accepted Manuscript , DOI: 10.1039/C7TX00074J

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