Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.



LncRNA-MALAT1 as a novel biomarker of cadmium toxicity regulates cell proliferation and apoptosis

Author affiliations

Abstract

Cadmium (Cd) and its compounds are well-known human carcinogens, but the mechanisms underlying the carcinogenesis are not well understood. This study aimed to investigate whether lncRNA-MALAT1 could serve as a novel biomarker of Cd toxicity in cells, animals and Cd-exposed workers, and regulate cell proliferation, apoptosis, migration and invasion. MALAT1 expression increased gradually in CdCl2 transformed 16HBE cells. The cell apoptosis, migration and invasion were significantly inhibited, and the mRNA and protein expression of FOXC2, STAT, BAX, EGFR, and TGF-β1 reduced, but BCL-2 increased (P < 0.05) after silencing MALAT1 by siRNA in CdCl2 treated 16HBE cells of 15th and 35th passages. Cadmium increased MALAT1 expression in the lung of Cd-exposed rats in a dose-dependent manner. A significant positive correlation was observed between blood MALAT1 expression and urinary/blood Cd concentrations, and there were significant correlations of MALAT1 expression with the expressions of target genes in the lung of Cd-exposed rats and the blood of Cd exposed workers. This study suggests that the expression of MALAT1 is upregulated and regulates the cell cycle progression, proliferation, apoptosis, migration and invasion in Cd toxicity. MALAT1 may serve as a novel valuable biomarker of cadmium exposure and cadmium toxicity.

Graphical abstract: LncRNA-MALAT1 as a novel biomarker of cadmium toxicity regulates cell proliferation and apoptosis

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 26 Nov 2016, accepted on 13 Mar 2017 and first published on 17 Mar 2017


Article type: Paper
DOI: 10.1039/C6TX00433D
Citation: Toxicol. Res., 2017, Advance Article
  •   Request permissions

    LncRNA-MALAT1 as a novel biomarker of cadmium toxicity regulates cell proliferation and apoptosis

    Q. Huang, Q. Lu, B. Chen, H. Shen, Q. Liu, Z. Zhou and Y. Lei, Toxicol. Res., 2017, Advance Article , DOI: 10.1039/C6TX00433D

Search articles by author