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Issue 8, 2017
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Nanoscale engineering of hybrid magnetite–carbon nanofibre materials for magnetic resonance imaging contrast agents

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Abstract

Magnetic nanomaterials show significant promise as contrast agents for magnetic resonance imaging (MRI). We have developed a new highly efficient one-step procedure for the synthesis of magnetically-functionalised hollow carbon nanofibres, where (i) the carbon nanofibres act as both a template and a support for the nucleation and growth of magnetite nanoparticles and (ii) the structural (size, dispersity and morphology) and functional (magnetisation and coercivity) properties of the magnetic nanoparticles formed on nanofibres are strictly controlled by the mass ratio of the magnetite precursor to the nanofibres and the solvent employed during synthesis. We have shown that our magnetite-nanofibre materials are effectively solubilised in water resulting in a stable suspension that has been employed as a “negative” MRI contrast agent with an excellent transverse relaxivity (r2) of (268 ± 13) mM s−1, surpassing current commercial materials and state-of-the-art magnetic nanoscale platforms in performance for MRI contrast at high magnetic fields. The preparation and evaluation of this unique hybrid nanomaterial represents a critical step towards the realisation of a highly efficient “smart” MRI theranostic agent – a material that allows for the combined diagnosis (with MRI), treatment (with magnetic targeting) and follow-up of a disease (with MRI) – currently in high demand for various clinical applications, including stratified nanomedicine.

Graphical abstract: Nanoscale engineering of hybrid magnetite–carbon nanofibre materials for magnetic resonance imaging contrast agents

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Publication details

The article was received on 22 Sep 2016, accepted on 30 Jan 2017 and first published on 30 Jan 2017


Article type: Paper
DOI: 10.1039/C6TC04141H
Citation: J. Mater. Chem. C, 2017,5, 2167-2174
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    Nanoscale engineering of hybrid magnetite–carbon nanofibre materials for magnetic resonance imaging contrast agents

    O. N. Metelkina, R. W. Lodge, P. G. Rudakovskaya, V. M. Gerasimov, C. H. Lucas, I. S. Grebennikov, I. V. Shchetinin, A. G. Savchenko, G. E. Pavlovskaya, G. A. Rance, M. del Carmen Gimenez-Lopez, A. N. Khlobystov and A. G. Majouga, J. Mater. Chem. C, 2017, 5, 2167
    DOI: 10.1039/C6TC04141H

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