Jump to main content
Jump to site search


One-pot synthesis of glutathione-responsive amphiphilic drug self-delivery micelles of doxorubicin–disulfide–methoxy polyethylene glycol for tumor therapy

Author affiliations

Abstract

We present a novel glutathione-responsive amphiphilic drug self-delivery (DSD) micelle with one-pot synthesis to synergistically address the problems of controlled drug release, degradability, drug tracing and in vivo accumulated toxicity. The anticancer drug doxorubicin (DOX), disulfide-based diacrylate (DSDA) and amino-polyethylene glycol monomethyl ether were linked by Michael addition in one-pot synthesis. The accumulative release rate of DOX analogues with drug activity from the micelles was 67.9% under pH 7.4 and GSH = 1 mg mL−1 conditions after 72 h. The cell uptake experiment showed that the micelles of DOX–DSDA–PEG were indeed taken up by A549 cells and distributed to cell nuclei. The in vitro cell viability of A549 cells was evaluated by CCK-8 and Muse Annexin V & Dead Cell Kit. The results illustrated that the completely biodegradable micelles with glutathione-responsive bonds in the backbone are an effective drug self-delivery system for tumor therapy in the future.

Graphical abstract: One-pot synthesis of glutathione-responsive amphiphilic drug self-delivery micelles of doxorubicin–disulfide–methoxy polyethylene glycol for tumor therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Oct 2017, accepted on 30 Nov 2017 and first published on 30 Nov 2017


Article type: Communication
DOI: 10.1039/C7TB02817B
Citation: J. Mater. Chem. B, 2018, Advance Article
  •   Request permissions

    One-pot synthesis of glutathione-responsive amphiphilic drug self-delivery micelles of doxorubicin–disulfide–methoxy polyethylene glycol for tumor therapy

    X. Duan, T. Bai, J. Du and J. Kong, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C7TB02817B

Search articles by author

Spotlight

Advertisements