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Scavenging hydroxyl radicals of long-term stored water-soluble fullerene system by silk fibroin

Abstract

Fullerene has been investigated for use in intratracheal instillation and inhalation. However, its use may be compromised owing to the formation of reactive oxygen species (ROS) from long-term stored water-soluble fullerene system which will result in the pulmonary injury. In this study, we investigated the scavenging effect of hydroxy radicals (OH·) produced by water-soluble fullerene system using different concentrations of silk fibroin (SF). In addition, we elaborated the mechanism of OH· formation and scavenging, the degradation of water-soluble fullerene (WSF), the effects of OH· and WSF on the viability of endothelial cells (ECs). WSF was found to rapidly degrade when being incubated with SF at 4 C, which suggested that OH· and the deposition of WSF over 5 half-lives might be reduced by mixing WSF with SF. Moreover, it was observed that OH· and WSF could generate adverse effects on EC viability, and OH· produced by WSF system on day 55 could be scavenged by SF. Overall, this study indicated that SF as an antioxidant was capable of scavenging OH· and accelerating degradation of WSF, which provided further insight into the application of WSF in intratracheal instillation and inhalation.

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Publication details

The article was received on 22 Oct 2017, accepted on 25 Dec 2017 and first published on 27 Dec 2017


Article type: Paper
DOI: 10.1039/C7TB02774E
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Scavenging hydroxyl radicals of long-term stored water-soluble fullerene system by silk fibroin

    Q. liu, Y. Liu, H. He, F. Wang, D. Yao, F. He, H. Liu and Y. Fan, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB02774E

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