Jump to main content
Jump to site search


Combating pathogens with Cs2.5H0.5PW12O40 nanoparticles: a new proton-regulated antimicrobial agent

Author affiliations

Abstract

The transfer of pathogens from contaminated surfaces to patients is one of the main causes of health care-associated infections (HCAIs). Cases of HCAIs due to multidrug-resistant organisms have been growing worldwide, whereas inorganic nano-antimicrobials are valuable today for the prevention and control of HCAIs. Here, we present a cesium salt of phosphotungstic heteropolyacid (Cs2.5H0.5PW12O40) as a promising nanomaterial for use in antimicrobial product technologies. This water-insoluble Keggin salt exhibits a broad biocide spectrum against Gram-positive and Gram-negative bacteria, yeasts, and filamentous fungi even under dark conditions. The Cs2.5H0.5PW12O40 nanoparticles (NPs) act as a proton-regulated antimicrobial whose activity is mediated on the release of hydronium ions (H3O+), yielding an in situ acidic pH several units below those tolerable by most of the fungal and bacterial nosocomial pathogens.

Graphical abstract: Combating pathogens with Cs2.5H0.5PW12O40 nanoparticles: a new proton-regulated antimicrobial agent

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Oct 2017, accepted on 01 Dec 2017 and first published on 01 Dec 2017


Article type: Paper
DOI: 10.1039/C7TB02763J
Citation: J. Mater. Chem. B, 2018, Advance Article
  •   Request permissions

    Combating pathogens with Cs2.5H0.5PW12O40 nanoparticles: a new proton-regulated antimicrobial agent

    R. H. Piva, M. C. Rocha, D. H. Piva, O. R. K. Montedo, H. Imasato, I. Malavazi and U. P. Rodrigues-Filho, J. Mater. Chem. B, 2018, Advance Article , DOI: 10.1039/C7TB02763J

Search articles by author

Spotlight

Advertisements