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Quenched hexacene optoacoustic nanoparticles

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Abstract

Optoacoustic (photoacoustic) imaging enables high-resolution optical imaging at depths well beyond optical microscopy, revolutionizing optical interrogation of tissues. Operation in the near-infrared (NIR) is nevertheless necessary to capitalize on the technology potential and reach depths of several centimeters. Using Flash NanoPrecipitation for highly-scalable single-step encapsulation of hydrophobic hexacene at self-quenching concentrations, we propose quenched fluorescence-dye nanoparticles as a potent alternative to NIR metal nanoparticles for strong optoacoustic signal generation. Comprehensive hexacene-based nanoparticle characterization was based on a 5-step approach that examined the physicochemical features (Step 1), optoacoustic signal generation (Step 2), stability (Step 3), biocompatibility (Step 4) and spectral sensitivity (Step 5). Using this characterization framework we showcase the discovery of two nanoparticle formulations, QH2-50 nm and QH2-100 nm that attain superior stability characteristics and optimal optoacoustic properties compared to gold standards commonly employed for near-infrared optoacoustics. We discuss encapsulation and self-quenching (ESQ) of organic dyes as a promising strategy to generate optimal optoacoustic particles.

Graphical abstract: Quenched hexacene optoacoustic nanoparticles

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Publication details

The article was received on 02 Oct 2017, accepted on 10 Oct 2017 and first published on 27 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB02633A
Citation: J. Mater. Chem. B, 2017, Advance Article
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    Quenched hexacene optoacoustic nanoparticles

    A. Nunes, V. J. Pansare, N. Beziere, A. K. Ntoukas, J. Reber, M. Bruzek, J. Anthony, R. K. Prud’homme and V. Ntziachristos, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB02633A

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