Jump to main content
Jump to site search

Issue 47, 2017
Previous Article Next Article

Topographical impact of silver nanolines on the morphology of neuronal SH-SY5Y Cells

Author affiliations

Abstract

An extracellular environment is critical in neuronal development and growth. Changes in neuronal morphology, neuron adhesion, and even the rate of neurite formation, can be modified by both the chemical and physical properties of interfacing substrates. Topography has a major impact on neuronal growth. Neuronal behavior and morphology are affected by the size, shape and pattern of the topographic elements. Combining topography with active materials may lead to enhanced influence. This paper demonstrates the effects of silver nanolines (AgNLs) on the growth pattern of SH-SY5Y cells. The morphology of the cells atop the nanotopographical substrates is measured, revealing a significant promoting effect. The number of neurites initiating from the soma is larger in SH-SY5Y cells plated on AgNLs than in control samples. The cells also exhibit an increase in neurite branching points towards more complex structures. These results indicate that substrates decorated with nanotopography affect cellular growth in a way that may be useful for enhanced regeneration, opening new possibilities for electrode and implant design.

Graphical abstract: Topographical impact of silver nanolines on the morphology of neuronal SH-SY5Y Cells

Back to tab navigation

Supplementary files

Publication details

The article was received on 17 Sep 2017, accepted on 15 Nov 2017 and first published on 15 Nov 2017


Article type: Paper
DOI: 10.1039/C7TB02492D
Citation: J. Mater. Chem. B, 2017,5, 9346-9353
  •   Request permissions

    Topographical impact of silver nanolines on the morphology of neuronal SH-SY5Y Cells

    I. Nissan, H. Schori, V. B. Kumar, M. A. Passig, O. Shefi and A. Gedanken, J. Mater. Chem. B, 2017, 5, 9346
    DOI: 10.1039/C7TB02492D

Search articles by author

Spotlight

Advertisements