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Issue 48, 2017
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Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery

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Abstract

We synthesized a new type of upper critical solution temperature (UCST) thermally responsive polymer (TRP) with varying responsive temperatures (cloud points). We then grafted one of the TRPs with a cloud point of 42 °C onto the surface of mesoporous silica nanoparticles (MSNs) using disulfide bonds to achieve a novel, dual responsive release system. With this system, the cargo release profiles are responsive to both temperature and reducing agents. When loaded with doxorubicin hydrochloride (DOX), the system could deliver DOX into breast cancer cells (SK-BR-3) in a controlled fashion and present high toxicity.

Graphical abstract: Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery

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Publication details

The article was received on 10 Sep 2017, accepted on 20 Nov 2017 and first published on 21 Nov 2017


Article type: Communication
DOI: 10.1039/C7TB02429K
Citation: J. Mater. Chem. B, 2017,5, 9497-9501
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    Dually responsive mesoporous silica nanoparticles regulated by upper critical solution temperature polymers for intracellular drug delivery

    M. Hei, J. Wang, K. Wang, W. Zhu and P. X. Ma, J. Mater. Chem. B, 2017, 5, 9497
    DOI: 10.1039/C7TB02429K

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