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Robust and Thermoplastic Hydrogels with surface micro-patterns for Highly Orienting Growth of Osteoblasts

Abstract

Fabricating of biocompatible hydrogels with high strength, high precision patterns and arbitrary 3D shapes is extremely desired soft platforms in the biomedicine fields. On the basis of the thermal-reversible sol-gel transition of agarose and formation of nanofibers below 35 °C, a robust and thermoplastic hydrogel (TPG) was fabricated by in-suit polymerizing acrylamide in the matrix. The tensile fracture stress/strain values of TPG were unexpectedly higher than those of both agarose and polyacrylamide hydrogels. The TPG could reversibly soften and harden by heating and cooling treatment, leading to an excellent mechanical recoverability and reprocessing ability. Thus, arbitrary 3D-shaped hydrogels and micro-patterns embossed on the TPG surface with a high resolution of 1μm were constructed. The rigid TPG exhibited remarkable affinity for the adhesion and proliferation of cells. More importantly, the TPG hydrogels with microgrooves could highly guidethe orientation growth of osteoblasts, showing potential applications in the field of tissue engineering.

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Publication details

The article was received on 07 Sep 2017, accepted on 10 Oct 2017 and first published on 10 Oct 2017


Article type: Communication
DOI: 10.1039/C7TB02412F
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Robust and Thermoplastic Hydrogels with surface micro-patterns for Highly Orienting Growth of Osteoblasts

    J. Guo, J. Duan, S. Wu, J. Guo, C. Huang and L. Zhang, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB02412F

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