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Aggregation-induced emission (AIE)-Active Fluorescent Probes with Multisite-Binding Sites toward ATP Sensing and the Live Cell Imaging

Abstract

Aggregation-induced emission (AIE)-active compounds are attractive fluorescent materials for applications in chemical and biological sensing. That effect of such materials amplifies changes in the fluorescence signal due to the physical states transformation from aggregation to disaggregation, which can be employed for detecting various analytes with high sensitivity. Especially, the specific bio-active analytes recognition is a very interesting but also a challenging work. In this paper, we report a set of novel AIE-active fluorescence probes containing pyridiniums and boricacid groups (TPA-PP, TPA-PPA-1, TPA-PPA-2, TPA-PPA-3), which has been developed for adenosine 5'-triphosphate (ATP) recognition. These probes with two type interaction modes and multiple connection sites toward ATP molecules are able to selectively discriminate ATP among other bioactive anions with a significant enhancement in fluorescence emission. Especially, in the application of cell imaging, with the amount of positive charges and boric acid group increase further and further, probes can penetrate into cells, then enrich into nucleus very specifically. These results clearly demonstrated that the newly developed sensors are suitable for specific tracing of different cell organelle with a high visualized solution and retention ability. Therefore, all of them are confirmed as a promising alternative for live cell imaging in the future.

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Publication details

The article was received on 07 Sep 2017, accepted on 22 Sep 2017 and first published on 22 Sep 2017


Article type: Paper
DOI: 10.1039/C7TB02399E
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Aggregation-induced emission (AIE)-Active Fluorescent Probes with Multisite-Binding Sites toward ATP Sensing and the Live Cell Imaging

    H. Ma, M. Yang, C. Zhang, Y. Ma, Y. Qin, Z. Lei, L. Chang, L. Lei, T. Wang and Y. Yang, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB02399E

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