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Issue 47, 2017
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Copper metal–organic polyhedra nanorods with high intrinsic peroxidase-like activity at physiological pH for bio-sensing

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Abstract

Enzyme-mimicking nanomaterials (nanozymes) have been used to catalyze enzyme-like reactions for various applications. Despite these favorable properties, peroxidase-mimicking nanozymes suffer from the optimum reaction occurring in acidic solutions, which greatly limits their applications in biological systems. Herein, we demonstrate that copper Metal–Organic Polyhedra (Cu-MOP) nanorods exhibit high peroxidase-mimicking activity at a physiological pH value. Cu-MOP nanorods catalyze the generation of strong chemiluminescence signals in the presence of luminol/H2O2 and the oxidation of 2,2′-azinobis-(3-ethylbenzthiazoline-6-sulphonate acid) (ABTS) by H2O2 produces a green color reaction in a neutral pH solution. The Cu-MOP nanorod driven generation of color reactions is applied to develop a H2O2 sensor, and furthermore is implemented to develop a glucose detection platform.

Graphical abstract: Copper metal–organic polyhedra nanorods with high intrinsic peroxidase-like activity at physiological pH for bio-sensing

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Publication details

The article was received on 06 Sep 2017, accepted on 12 Nov 2017 and first published on 13 Nov 2017


Article type: Paper
DOI: 10.1039/C7TB02388J
Citation: J. Mater. Chem. B, 2017,5, 9365-9370
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    Copper metal–organic polyhedra nanorods with high intrinsic peroxidase-like activity at physiological pH for bio-sensing

    Y. Qin, Q. Zhang, Y. Li, X. Liu, Z. Lu, L. Zheng, S. Liu, Q. Cao and Z. Ding, J. Mater. Chem. B, 2017, 5, 9365
    DOI: 10.1039/C7TB02388J

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