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Copper metal-organic polyhedra nanorods with high intrinsic peroxidase-like activity at physiological pH for bio-sensing

Abstract

Enzyme-mimicking nanomaterials (nanozymes) have been used to catalyze enzyme-like reactions for various applications. Despite these favorable properties, peroxidase mimicking nanozymes suffer from its optimum reaction occurs in acidic solution, which greatly limits its applications in biological systems. Herein, we demonstrate that copper Metal-Organic Polyhedra (Cu-MOP) nanorods exhibit highly peroxidase mimicking activity at physiological pH value. Cu-MOP nanorods catalyze the generation of strong chemiluminescence signals in the presence of luminol/H2O2 and the oxidation of 2,2'-Azinobis-(3-ethylbenzthiazoline-6-sulphonate acid (ABTS) by H2O2 produces a green color reaction in neutral pH solution. The Cu-MOP nanorods driven generation of color reactions are applied to develop a H2O2 sensor, and furthermore are implemented to develop a glucose detection platform.

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Publication details

The article was received on 06 Sep 2017, accepted on 12 Nov 2017 and first published on 13 Nov 2017


Article type: Paper
DOI: 10.1039/C7TB02388J
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Copper metal-organic polyhedra nanorods with high intrinsic peroxidase-like activity at physiological pH for bio-sensing

    Y. Qin, Q. Zhang, Y. Li, X. Liu, Z. Lu, L. Zheng, S. Liu, Q. Cao and Z. Ding, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB02388J

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