Jump to main content
Jump to site search


A reactive oxygen species (ROS)-responsive low molecular weight gel co-loaded with doxorubicin and Zn(II) phthalocyanine tetrasulfonic acid for combined chemo-photodynamic therapy

Author affiliations

Abstract

Low molecular weight gels (LMWGs) have significant advantages in drug delivery such as high drug loading capacity, in situ delivery of drug to the lesion site, sustaining drug release with excellent bioavailability, and minimized side effects. Here, we synthesized a reactive oxygen species (ROS)-responsive gelator to prepare an injectable gel. An anticancer drug, doxorubicin hydrochloride (DOX), and a photosensitizer, Zn(II) phthalocyanine tetrasulfonic acid (ZnPCS4), were loaded into the gel for combined chemo-photodynamic therapy. The ROS-responsive gelator was characterized by proton nuclear magnetic resonance (1H NMR) and the morphology of gels was investigated by scanning electron microscopy (SEM). The rheological properties and destruction–recovery capability of both blank and drug-loaded gels were studied. The cytotoxicity of LMWGs against 3T3 fibroblasts and 4T1 breast cancer cells was tested. The in vitro drug release of both drugs was studied and the in vivo anticancer activities of DOX–ZnPCS4-coloaded LMWGs were investigated in tumor-bearing mice. The results revealed that the injectable ROS-responsive DOX–ZnPCS4-coloaded LMWGs exhibited excellent anti-tumor efficacy by a synergistic therapy.

Graphical abstract: A reactive oxygen species (ROS)-responsive low molecular weight gel co-loaded with doxorubicin and Zn(ii) phthalocyanine tetrasulfonic acid for combined chemo-photodynamic therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Sep 2017, accepted on 06 Nov 2017 and first published on 08 Nov 2017


Article type: Paper
DOI: 10.1039/C7TB02359F
Citation: J. Mater. Chem. B, 2017, Advance Article
  •   Request permissions

    A reactive oxygen species (ROS)-responsive low molecular weight gel co-loaded with doxorubicin and Zn(II) phthalocyanine tetrasulfonic acid for combined chemo-photodynamic therapy

    L. Xu, M. Zhao, Y. Yang, Y. Liang, C. Sun, W. Gao, S. Li, B. He and Y. Pu, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB02359F

Search articles by author

Spotlight

Advertisements