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Enhanced diabetic wound healing by electrospun core-sheath fibers loaded with dimethyloxalylglycine

Abstract

The destabilization and dysfunction of hypoxia-inducible factor 1α (HIF-1α) caused by hyperglycemia is an important reason for delayed healing in diabetic chronic wounds. Hence, it is well worth designing HIF-1α-stabilizing wound dressings to counteract the effects of a hyperglycemic microenvironment. Dimethyloxalylglycine (DMOG), a competitive inhibitor of prolyl hydroxylases (PHDs), can stabilize HIF-1α by inhibiting its degradation. Therefore, in this study, we developed DMOG-releasing nanofibrous wound dressings for diabetic wound healing. We systematically evaluated the regulation of DMOG-releasing nanofibers on human foreskin fibroblasts (HFFs) with in vitro biological assessments. The results showed that the release of DMOG from nanofibers can be effectively controlled by the co-axial structure of nanofibers. The sustained release of DMOG in co-axial nanofibers enhanced the migration and expression of wound healing-related genes in HFFs. In addition, we conducted an in vivo study using a diabetic wound model in rat to examine the effects of DMOG-loaded nanofibrous wound dressings on the wound healing process. The in vivo study confirmed that the DMOG incorporated in nanofibers stabilized local HIF-1α levels in wounds and subsequently improved the diabetic wound regeneration by accelerating the re-epithelialization, angiogenesis and wound closure, which was consistent with the in vitro evaluation. The results suggest that the DMOG-releasing nanofibers may be a promising functional wound dressing for diabetic wounds.

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Publication details

The article was received on 01 Sep 2017, accepted on 01 Dec 2017 and first published on 01 Dec 2017


Article type: Paper
DOI: 10.1039/C7TB02342A
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Enhanced diabetic wound healing by electrospun core-sheath fibers loaded with dimethyloxalylglycine

    W. Gao, L. Sun, X. Fu, Z. Lin, W. Xie, W. Zhang, F. Zhao and X. Chen, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB02342A

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