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Issue 38, 2017
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Non-invasively visualizing cell–matrix interactions in two-photon excited supramolecular hydrogels

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Abstract

Visualizing the role of extracellular matrix (ECM) in cell bioactivities in three-dimensional (3D) view is highly important for in-depth understanding of fundamental physiological issues in various in vitro experiments. Using current designs it is difficult to produce 3D biomimetic ECM with intrinsic fluorescence under non-invasive near-infrared excitation. Herein, we have designed and synthesized a series of non-conventional coumarin-derived hydrogelators, which can self-assemble to form nanofibrous 3D supramolecular hydrogels through C–H⋯O bonds and be excited by two-photon absorption, ensuring the direct and dynamic visualization of cell–matrix interactions with high resolution images in a 3D environment. Real-time monitoring of ECM-regulated dynamic cell behaviours is highly desirable for future basic and applied research.

Graphical abstract: Non-invasively visualizing cell–matrix interactions in two-photon excited supramolecular hydrogels

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Publication details

The article was received on 25 Aug 2017, accepted on 06 Sep 2017 and first published on 06 Sep 2017


Article type: Communication
DOI: 10.1039/C7TB02274C
Citation: J. Mater. Chem. B, 2017,5, 7790-7795
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    Non-invasively visualizing cell–matrix interactions in two-photon excited supramolecular hydrogels

    W. Ji, L. Li, O. Eniola-Adefeso, Y. Wang, C. Liu and C. Feng, J. Mater. Chem. B, 2017, 5, 7790
    DOI: 10.1039/C7TB02274C

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