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Blood Brain Barrier Permeable Gold Nanocluster for Targeted Brain Imaging and Therapy: An in vitro and in vivo Study

Abstract

Blood brain barrier (BBB) is a dynamic interface, comprised of polarized endothelial cells, that separates brain from circulatory system. The highly protective nature of this tight junction impires diagnosis and treatment of brain disorders. In this study, we designed a sub atomic size, near infrared emitting, dual function glutathione gold cluster with high florescence yield to facilitate permeability of BBB, for imaging applications and drug delivery. The gold cluster was then modified with Levodopa(L-dopa), to utilize the large amino acid transporter 1 (LAT1) pathways to enhance the brain entry. Uptake and permeability of the nanoprobes were demonstrated using an established model of BBB, comprising brain endothelial cells (bEnd.3). The uptake and the clearance of L-dopa modified cluster was faster than the glutathione cluster. L-dopa modified cluster supports the slow and sustained delivery of a model drug, pilocarpine to the brain. Results of in vivo imaging and drug release in normal mice holds promise for considering the probe for early diagnosis of brain diseases, when the barrier is not disrupted, and for subsequent drug treatment.

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Publication details

The article was received on 22 Aug 2017, accepted on 09 Oct 2017 and first published on 09 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB02247F
Citation: J. Mater. Chem. B, 2017, Accepted Manuscript
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    Blood Brain Barrier Permeable Gold Nanocluster for Targeted Brain Imaging and Therapy: An in vitro and in vivo Study

    L. V. Nair, R. V. Nair, S. J. Shenoy, A. Thekkuveettil and R. S. Jayasree, J. Mater. Chem. B, 2017, Accepted Manuscript , DOI: 10.1039/C7TB02247F

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