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Ferrocene covalently confined in porous MOF as signal tag for highly sensitive electrochemical immunoassay of amyloid-β

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Abstract

Here a new type of ferrocene confined in a metal–organic framework (Fc-Zn-MOF) as an electrochemical signal tag has been synthesized and applied in an immunosensor for highly sensitive amyloid-β (Aβ, as a model protein) detection. In the present work, an electrochemically active molecule of Fc was covalently bonded in a Zn-MOF via postsynthetic modification to obtain a flower-like Fc-Zn-MOF, in which the high-content Fc signal units were periodically arranged in a well-defined porous structure, showing enhanced electrochemical activity. As noticed, Fc molecules are chemically anchored on the Zn-MOF, which avoids leakage of signal molecules, protects those electrochemical activities from potential damage and exhibits good stability. The Fc-Zn-MOF signal tag was further explored in constructing an electrochemical immunosensor for Aβ detection, with a linear range from 0.0001 to 100 ng mL−1 and a detection limit of 0.03 pg mL−1, showing improved analytical performance. This work presents an example of an Fc-MOF as a signal tag for Aβ detection, which would encourage atypical research lines for MOFs in bioassays where the introduction of ordered structures promises new opportunities.

Graphical abstract: Ferrocene covalently confined in porous MOF as signal tag for highly sensitive electrochemical immunoassay of amyloid-β

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Publication details

The article was received on 21 Aug 2017, accepted on 02 Oct 2017 and first published on 02 Oct 2017


Article type: Paper
DOI: 10.1039/C7TB02240A
Citation: J. Mater. Chem. B, 2017, Advance Article
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    Ferrocene covalently confined in porous MOF as signal tag for highly sensitive electrochemical immunoassay of amyloid-β

    J. Han, M. Zhang, G. Chen, Y. Zhang, Q. Wei, Y. Zhuo, G. Xie, R. Yuan and S. Chen, J. Mater. Chem. B, 2017, Advance Article , DOI: 10.1039/C7TB02240A

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